Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0329

Protein Name

Aquaporin-1

Gene Name

AQY1; AQY1-1

Organism

Saccharomyces cerevisiae (Bakers yeast)

Length

327 amino acids

AlphaFoldDB

AF-P0CD92-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across membranes. Involved in sporulation; freeze tolerance and osmotolerance. Is non-functional in most laboratory strains.

Sequence

MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISRDTLRNHFIAAVGEFCGTFMFLWCAYVICNVANHDVALVAAPDGSHPGQLIMIAIGFGFSVMFSIWCFAGVSGGALNPAVSLSLCLARAVSPTRCVVMWVSQIVAGMAAGGAASAMTPGEVLFANSLGLGCSRTRGLFLEMFGTAILCLTVLMTAVEKRETNFMAALPIGISLFIAHVALTAYTGTGVNPARSLGAAVAARYFPHYHWIYWIGPLLGSILAWSVWQLLQILDYTTYVTAEKAASTKEKAQKKVKPAVPLLWLKSNFPLLFFISRSLALNVIIFGKN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1074/jbc.273.42.27565; 10.1006/bbrc.1999.0425; 10.1002/1097-0061(200007)16:10<897::aid-yea583>3.0.co;2-t; 10.1128/aem.68.12.5981-5989.2002; 10.1128/aem.70.6.3377-3382.2004; 10.1073/pnas.0404337101